Transplants And Diabetes
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| Term Paper Title | Transplants And Diabetes |
| # of Words | 366 |
| # of Pages (250 words per page double spaced) | 1.46 |
Transplants and Diabetes
Three Toronto scientists have developed an organ
transplant procedure that could, among its many
benefits, reverse diabetes. The procedure was
developed by Bernard Leibel, Julio Martin and
Walter Zingg at the University of Toronto and the
Hospital for Sick Children. The story of their work
began in 1978, when they delved into research
which had never before been tried. They wanted
to determine if the success rate of organ
transplants would increase if the recipient was
injected with minute amounts of organ tissue prior
to the transplant. The intention was to adapt the
recipient to the transplanted tissue and thereby
raise the threshold of rejection. In the case of the
diabetes experiment, this meant injecting rats with
pancreatic tissue before transplanting islets of
Langerhans, small clusters of cells scattered
throughout the pancreas which produce insulin,
glucagon, and somatostatin. In their first
experiment, outbred Wistar rats were injected
with increasing amounts of minced pancreas from
unrelated donor rats for one year while a control
group was left untreated. Then both the treated
and control groups received injections of
approximately 500-800 islets of Langerhans from
unrelated donors. Of the five treated animals, two
became clinically and biochemically permanently
normal. Six months later, Martin examined the
cured rats
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