Current Status Of Malaria Vaccinology
Below is a free term papers summary of the paper "Current Status Of Malaria Vaccinology." If you sign up, you can be reading the rest of this term papers in under two minutes. Registered users should login to view this term paper.
| Term Paper Title | Current Status Of Malaria Vaccinology |
| # of Words | 2053 |
| # of Pages (250 words per page double spaced) | 8.21 |
Current Status of Malaria Vaccinology
Current Status of Malaria Vaccinology
In order to assess the current status of malaria vaccinology one must first take
an overview of the whole of the whole disease. One must understand the disease
and its enormity on a global basis.
Malaria is a protozoan disease of which over 150 million cases are reported per
annum. In tropical Africa alone more than 1 million children under the age of
fourteen die each year from Malaria. From these figures it is easy to see that
eradication of this disease is of the utmost importance.
The disease is caused by one of four species of Plasmodium These four are P.
falciparium, P .malariae, P .vivax and P .ovale. Malaria does not only effect
humans, but can also infect a variety of hosts ranging from reptiles to monkeys.
It is therefore necessary to look at all the aspects in order to assess the
possibility of a vaccine.
The disease has a long and complex life cycle which creates problems for
immunologists. The vector for Malaria is the Anophels Mosquito in which the life
cycle of Malaria both begins and ends. The parasitic protozoan enters the
bloodstream via the bite of an infected female mosquito. During her feeding she
transmits a small amount of anticoagulant and haploid sporozoites along with
saliva. The sporozoites head directly for the hepatic cells of the liver where
they multiply by asexual fission to produce merozoites. These merozoites can now
travel one of two paths. They can go to infect more hepatic liver cells or they
can attach to and penetrate erytherocytes. When inside the erythrocytes the
plasmodium enlarges into uninucleated cells called trophozites The nucleus of
this newly formed cell then divides asexually to produce a schizont, which has
6-24 nuclei.
Now the multinucleated schizont then divides to produce mononucleated merozoites
. Eventually the erythrocytes reaches lysis and as result the merozoites enter
the bloodstream and infect more erythrocytes. This cycle repeats itself every
48-72 hours (depending on the species of plasmodium involved in the original
infection) The sudden release of merozoites toxins and erythrocytes debris is
what causes the fever and chills associated with Malaria.
Of course the disease must be able to transmit itself for survival. This is done
at the erythrocytic stage of the life cycle. Occasionally merozoites
differentiate into macrogametocytes and microgametocytes. This process does not
cause lysis and there fore the eryth
This is not the end of the termpaper! Register below to see the complete version of this term paper.
| Membership Plans |
Credit Card |
Check |
 |
| 1 month membership |
|
3 month membership
(You Save 50%) |
|
6 month membership
(You Save 67%) |
|
| 
