Prions

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Term Paper Title	Prions
# of Words	1634
# of Pages (250 words per page double spaced)	6.54

Prions

Prions

     Prions have been a mistery for scientists from the day they where
discovered. Prions act like viruses but they are not. Their structure and
chemistry are unknown. They are believed to be proteins but that is yet to be
completely proved.

     Prion stands for “proteinaceous infectious particles”. Prions are known
to cause many diseases involved with nervous systems like the brain. They are
the ones that cause the well known “ mad cow ” disesase in Britain and “scrapie”
for animals. For humans they are known to cause a rare disease in Papua New
Guinea called Kuru ( or “laughing death”) which striked only the cannibals in
the Highlander tribes. Investigation led to the discovery of prions inside the
of the victims brains that were eaten by the tribesmen that when they died, as a
sign of respect their brains where eaten and the chain went on and on.

     The thing that makes prions so special is the fact that they lack the
basic elements for reproduction, deoxyribonucleic acid and ribonucleic acid DNA
and RNA respectively. This is what has given science a great deal of doubt as
this would give the dogma of the beginning of live a radical turn.

     Prions have been in research for many years with experiments like the
one done by Stanley B. Pruiser and his team of scientists at the School of
Medicine of the University of California at San Francisco in which a study was
carried out on mice to see if he was able to purify the scrapie agent ,another
prion disease, in mice. But mice as humans took very long to develope the
disease, for example Gerstmann-Straussler-Scheinker disease or fatal familial
insomnia, which appear mostly on humans which have passed the age of forty and
only in very rare cases before, so the experiment was changed to hamsters as
these die faster because developed the disease earlier. One of the methods used
for this purification process was using a centrifuge, that separates the
component of a  mixture according to their size and density. After a decade of
experiments using the centrifuge method and other chemical methods, several
discoveries were made : It was found out that the infectious particles were
extremely heterogencous in size and density, the scrapie agent can be found in
many molecular forms and the biological activity of the scrapie agent depends on
a protein (PrP, called later when discovered it was a single molecular specie
protein). This protein was found to be a glycoprotein (PrP): sugars are bounded
to the amino a...

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