Hypogravitational Osteoporosis

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Term Paper Title	Hypogravitational Osteoporosis
# of Words	1261
# of Pages (250 words per page double spaced)	5.04

Hypogravitational Osteoporosis

Osteoporosis: a
condition characterized by an absolute decrease in
the amount of bone present to a level below which
it is capable of maintaining the structural integrity
of the skeleton. To state the obvious, Human
beings have evolved under Earth's gravity "1G".
Our musculoskeleton system have developed to
help us navigate in this gravitational field, endowed
with ability to adapt as needed under various
stress, strains and available energy requirement.
The system consists of Bone a highly specialized
and dynamic supporting tissue which provides the
vertebrates its rigid infrastructure. It consists of
specialized connective tissue cells called
osteocytes and a matrix consisting of organic
fibers held together by an organic cement which
gives bone its tenacity, elasticity and its resilience.
It also has an inorganic component located in the
cement between the fibers consisting of calcium
phosphate [85%]; Calcium carbonate [10%] ;
others [5%] which give it the hardness and rigidity.
Other than providing the rigid infrastructure, it
protects vital organs like the brain], serves as a
complex lever system, acts as a storage area for
calcium which is vital for human metabolism,
houses the bone marrow within its mid cavity and
to top it all it is capable of changing its architecture
and mass in response to outside and inner stress.
It is this dynamic remodeling of bone which is of
primary interest in microgravity. To feel the impact
of this dynamicity it should be noted that a bone
remodeling unit [a coupled phenomena of bone
reabsorption and bone formation] is initiated and
another finished about every ten seconds in a
healthy adult. This dynamic system responds to
mechanical stress or lack of it by increasing the
bone mass/density or decreasing it as per the
demand on the system. -eg; a person dealing with
increased mechanical stress will respond with
increased mass / density of the bone and a person
who leads a sedentary life will have decreased
mass/density of bone but the right amount to
support his structure against the mechanical
stresses she/she exists in. Hormones also play a
major role as seen in postmenopausal females
osteoporosis (lack of estrogens) in which the rate
of bone reformation is usually normal with the rate
of bone re-absorption increased. In Skeletal
system whose mass represent a dynamic
homeostasis in 1g weight- bearing,when placed in
microgravity for any extended period of time
requiring practically no we...

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